Lack of experience is the biggest obstacle preventing the stay at home mom from finding a job. In my personal experience, you really have to sell yourself, and make sure the potential employer knows why they would benefit from hiring you. I had one employer who did have a strong interest in me, due to my knowledge of food, especially gourmet food. (I did not pursue that opening,however, as it turned out to be just a deli clerk position). It is vital to try and find something in the job opening that fits your skills, and sell that fit to the employer.
In the case of the job which I just landed, it is a local job, so I sold the fact that I lived nearby, and I also talked about the fact that I am highly organized, which is a must for the job.